Sat, 2 Aug 2014

Formulation and In vitro Evaluation of Microbially Triggered Colon Specific drug delivery of Satranidazole using Sesbania gum

Dinesh Chandra*1, Ambikeshwar Pratap Singh1, Pankaj Kumar Singh2, Jayant Kumar Maurya3, Tirth Raj4

1.Kamla Nehru Institute of Management and Technology, Faridipur, Sultanpur, Uttar Pradesh, India


ABSTRACT

The colon drug delivery system has gained recent importance in delivery of the drug to the colon. These system facilitate the delivery of the drug to the colon and mainly releases the drug in the colonic environment and thereby reduces various side effects of conventional dosage forms like lower dose is required and hence lowering the side effects caused by higher doses. In the present study natural polysaccharide approach is employed and sesbania gum powder was used as a carrier for delivery of the drug to the colon . Satranidazole was selected as a drug of choice because it is most potent nitroimidazole derivative and clinically useful against common protozoa, it is twice as effective as other nitroimidazoles against amoebiasis. Colon targeted tablet of satranidazole can maintain minimum inhibitory concentration for desired duration in fewer doses with fewer side effects. The aim of the present research work is to develop core tablets of satranidazole and compression coated with different ratios of sesbania gum powder. All the formulations were then subjected for evaluation and were tested for hardness, drug content uniformity an in vitro drug release studies. The compression coated formulation CCS 2 released less than 5% of satranidazole drug in the physiological environment of stomach and intestine, when the dissolution studies was further continued in simulated colonic fluids the compression coated tablets with 150mg of sesbania gum powder released another 70% of satranidazole in the colon after degradation by colonic bacteria at the end of 12 hrs.

Keywords: Satranidazole, compression coated, Microbially triggered, polysaccharides, colon targeted tablets.


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