Mon, 20 Nov 2017

Formulation and Evaluation of Mouth Dissolving Tablets of Gliclazide Containing Fenugreek Seed Powder

Dinesh Chandra*1, Pankaj Kumar Singh1, Ambikeshwar Pratap Singh2, Tirth Raj3

1.Kamla Nehru Institute of Management and Technology, Faridipur,Sultanpur, Uttar Pradesh, India


ABSTRACT

Tablet is the most popular dosage form of all existing dosage forms , but in some cases due to the large size of dosage forms, in case of uncooperative, pediatric and dysphasia patients, it may create  problems, to overcome this , a new form of dosage form is developed, which is known as fast dissolving tablets or mouth dissolving tablets. These dosage forms are also used to attain instant higher concentration of drug in body for immediate actions. Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Fenugreek seed powder was added to this formuation because of  its various pharmacological benefits as well as its self disintegrating property. Mouth dissolving tablets were prepared using direct compression method .Formulations were optimized to develop tablets having minimum possible disintegration time. Tablets were evaluated for hardness, weight variation, friability, wetting time, disintegration time and stability. The main objective of the present research is formulation and evaluation  of mouth dissolving tablets of gliclazide which is an antidiabetic drug ,containing fenugreek seed powder as disintegrating agent.

Keywords : mouth dissolving tablets, gliclazide, fenugreek seed powder, solid dispersion, evaluation.


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