DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Synthesis, Antimicrobial and Anticancer Studies of Isatin Derivatives of Sparfloxacin

Sirajunisa Talath*1, Bhoomendra A. Bhongade1

1.Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAKMHSU, POB 11172, Ras Al Khaimah, UAE


Mannich bases of sparfloxacin were synthesized from the reaction of 5-acetylamino-1-cyclopropyl-7-(3΄,5΄-dimethyl-piperazin-1-yl)-6,8-difluoro-4-oxo1,4-dihydro-quinoline-3-carboxylic acid with formaldehyde and several isatin derivatives. The structures of the synthesized compounds were elucidated from the IR, 1H NMR, 13C NMR and FAB Mass data. The synthesized compounds were evaluated for the antibacterial, antitubercular and anticancer activity. The compounds showed good activity against Gram-positive bacteria and moderate activity against tested Gram-negative bacteria. The MIC for the compounds against M. tuberculosis H37Rv strain was <6.25 µg/mL while the IC50 values against cancer cell lines SW480, HeLa, A549 and HepG2 was in the range of 18.31- >50 µg/mL. The most potent compound in this series 3c exhibited enhanced antibacterial activity than sparfloxacin against S. aureus, Bacillus Sp while the anticancer activity was in the range of 18.31- 23.61 µg/mL.

Keywords : Sparfloxacin, Mannich bases, Isatin, Antibacterial, Antitubercular, Anticancer.

[PDF]   Viewed: 1738   Downloaded: 214
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter