DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Formulation and Evaluation of Proniosomal Gel of Flurbiprofen

Dinesh Chandra*1, Ashish Kumar1, Rakesh singh1 , Tirth Raj1, Jayant Kumar Maurya1, Shrikant Verma2

1.Kamla Nehru Institute of Management and Technology, Sultanpur, India. Babu Banarasi Das University, Lucknow, India


The aim of present study,  To formulate and characterized  proniosome contain flurbiprofen in a gel formulation for the treatment of rheumatoid arthritis and enhanced skin targeted effect, sustained & prolonged drug release, enhanced skin bioavailability by using different type of non ionic surfactant & cholesterol. The batches were designed using Box Behnken Design and prepared by coacervation phase separation method. Optimized formulation (PNGopt) showed drug entrapment efficiency of 74.46% and particle size 215nm. In-vitro drug release from PNGopt was found to be 84.15 in 24 hrs. The In-vitro drug release was best explained by zero order kinetics as the plot showed highest linearity and release was governed by Quasi Fickian diffusion.

Keywords: Proniosomes, Flurbiprofen,Brij93,in-vitro release, Stability  studies

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