Mon, 20 Nov 2017

Solid Dispersion- A way to Enhance Solubility of Quetiapine Fumarate

Mohit Shah*1,Zakera Farooqui1, Jainam Shah1,Nirmal Shah1,Sonali Sheorey1

1.Department of Pharmaceutics, Rofel Shri G.M. Bilakhia College of Pharmacy, Namdha Road,Vapi 396191,Gujarat


ABSTRACT

Quetiapine Fumarate is a antipsychotic agent indicated for treatment of Schizophrenia and Bipolar disorder. Quetiapine Fumarate is BCS Class II drug which is  poorly water soluble and may show dissolution limited absorption. Hence to improve dissolution rate and bioavailability, Solid dispersion of Quetiapine Fumarate by Solvent Evaporation method were prepared using 1:1, 1:2, 1:3, 1:4 and 1:5 ratios of Quetiapine Fumarate and Polyvinyl Pyrrolidone K30(PVP K30). The solid dispersion (SD) was characterized for physical appearance, solubility, FTIR, DSC, XRD studies and in vitro dissolution studies. FTIR study revealed that there was no drug-carrier chemical interaction in Solid dispersion. DSC studies revealed that, the peak observed for the melting of Quetiapine Fumarate is found to be absent in SD with PVP K30 carrier. XRD studies suggested that there has been a large change in the nature of Quetiapine Fumarate in the solid dispersion. Solubility of Quetiapine Fumarate from SD increased in distilled water. The drug content was found to be high and uniformly distributed in the formulation. The in vitro dissolution studies were carried using USP type II (paddle) type dissolution apparatus. The prepared Solid dispersion showed marked increase in the dissolution rate of Quetiapine Fumarate than that of pure drug. The Solid dispersion with PVP K30 (1:5) by Solvent evaporation method showed faster dissolution rate as compared to other Solid dispersions. It is concluded that dissolution of the Quetiapine Fumarate could be improved by the Solid dispersion.

Keywords: Quetiapine Fumarate, bioavailability, Solid dispersion, dissolution.


[PDF]  Viewed: 3043  Downloaded: 466
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter