Sat, 18 Nov 2017

Simultaneous Estimation of Vildagliptin and Metformin in Bulk and Pharmaceutical Formulations by UV Spectrophotometry

 

Usharani Gundala*1, Chandra Shekar Bhuvanagiri 2, Devanna Nayakanti3

1. Research Scholar, JNTUA, Anantapur, A.P, India.

2. Professor, MLR Institute of Pharmacy, Hyderabad, A.P, India.

3. Director of OTRI, JNTUA, Anantapur, A.P, India.


 

ABSTRACT

A simple, accurate, precise and reproducible method has been developed for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in combined tablet dosage forms. As there are no reported UV methods for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in their combined dosage form, a need was felt to develop new methods to analyze the drugs simultaneously. The estimation was done by multi-wavelength technique, at wavelengths of 217 nm and 234 nm over the concentration ranges of 0.7µg/ml and 7 µg/ml with mean recovery 100% for both drugs Vildagliptin and Metformin hydrochloride respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guide lines. Thus the proposed method can be successfully applied for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in routine analysis work.

Keywords: Vildagliptin, Metformin, Simultaneous, Multi-wavelength, spectro-photometric.


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