DOI: 10.21276/ajptr
Fri, 19 Apr 2019

Preparation, Characterization and In Vitro Evaluation of Etoposide Loaded PCL Nanoparicles


Riddhi M. Dave*1, Rakesh K. Patel2

1 S.K.Patel Colleges of Pharmaceutical Education and Research, Ganpat University, Kherva-. Gujarat, INDIA



The present investigation involves the Preparation and Characterization of etoposide loaded PCL Composite micropartices on account to control initial burst release. The prepared composite particles were characterized physicochemically for Encapsulation efficiency, Mean particle size, Release kinetic and compared with nanoparticles and simple microparticles prepared by the same double emulsion method. The major objective of the present study is to incorporate a hydrophilic drug etoposide within hydrophobic polymer poly (ε-caprolactone) for the preparation of composite micro particles to minimize initial burst release of the drug which is generally associated with micro and nanoparticles. Micro particles and nanoparticles were prepared by W/O/W emulsion solvent extraction and W/O/W solvent evaporation method respectively using different ratios of drug to polymer (0.1:1, 0.2:1 and 0.4:1). These prepared nanoparticles were further fabricated in micro particles using double emulsion method in ratio of (0.05:1, 0.1:1, 0.2:1).When PCL nanoparticles were encapsulated into the microparticles, there was a large decrease in the burst release again; this decrease is much more marked when p < 0.05. When nanoparticles formulated in to composite micropartices the burst released is suppressed only 50% of the drug was released in 8 hrs. Therefore, the advantage of encapsulating nanoparticles in microparticles (composite microparticles) has been definitely demonstrated for a hydrophilic drug.

Keywords: Ex-Vitro, Microparticles, Nanoparticles

[PDF]   Viewed: 1295   Downloaded: 146
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter