Sat, 18 Nov 2017

Synthesis of Certain Bioactive Molecules Containing N-Glucosylated s-Triazines

 

Manjusha R.Ugale1*, Avinash.G.Ulhe2 and Baliram.N.Berad2

1.G.H.Raisoni Institute of Engineering and Technology for Women, Nagpur.

2.P.G .Department of Chemistry, RTM University, Nagpur, Maharashtra, INDIA, 440033.


 

ABSTRACT

A series of 6-tetra-O-acetyl-β-D-glucopyranosylimino 2 dimethylamino-4 aryl/alkyl imino-1,4,5,6 tetrahydro-1,3,5 triazines have been synthesized by the interaction of tetra-O-acetyl α-D glucopyranosyl bromide and various 1,3,5 triazines. The latter were synthesized by following the interaction of metformin hydrochloride and N-aryl/alkyl imino isocyanodichloride in chloroform medium. The identities of these new N-glucosylated triazines have been established on the basis of elemental analysis, I.R., NMR and mass spectral studies. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. Some of them showed moderate to less antimicrobial activity.

Keywords: N-glucosylated 1, 3 ,5 triazines, antimicrobial activity.


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