Sat, 18 Nov 2017

A Validated Non-Aqueous Potentiometric Titration Method for the Quantitative Determination of Oxolamine Citrate from Pharmaceutical Preparation

 

Rajan V. Rele1*, Sachin S. Patil1

1. Research laboratory of chemistry, D.G. Ruparel college, Matunga , Mumbai  400016.


 

ABSTRACT

A simple precise, rapid, accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of oxolamine citrate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.99 ) between 20 % to 100 % of 100 mg of drug substance weight. The percentage recovery of oxolamine citrate in the optimized method was between 99.773 to 101.229 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords: Oxolamine citrate, perchloric acid , potassium hydrogen phthalate ,glacial acetic acid.


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