Sat, 18 Nov 2017

The Non-Aqueous Potentiometric Determination of Pharmaceutically Potent Drug Aspirin

 

Pradip P. Deohate*, Vaishali R. Patil

1.Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science    Akola-444001, India.


 

ABSTRACT

The non-aqueous potentiometric determination of pharmaceutically potent drug aspirin by using isopropyl alcohol as the solvent and alcoholic KOH as the titrant has been carried out. The effect of solvent and concentration on potentiometric determination of aspirin has been studied followed by the estimation of aspirin in single component tablets. The titrations were carried out using glass and calomel electrode pair. The method was found to be convenient for assay of aspirin and results obtained are comparable with those obtained by IP method. Solvent isopropyl alcohol gives much more accurate result as compare to other solvents with minimum % error. In study of effect of concentration, the results obtained are more accurate with positive errors at low concentration whereas, negative errors at high concentration. The error is just +0.11% when 1.804 mg of aspirin was titrated. Confidence level of weight titrated and weight found in respect of aspirin is 0.46 which is statistically non significant.

Keywords: Non-aqueous, potentiometric determination, aspirin


[PDF]  Viewed: 1975  Downloaded: 315
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter