Sat, 18 Nov 2017

Comparative Study on Effect of Natural and Synthetic Superdisintegrants in Formulation of Lornoxicam Orodispersible Tablet

 

 

Ravi P. Gondaliya*1, Alpesh C. Arvadiya1, Sanket B. Dusunge1, Hitendra S. Mahajan1

1.R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India


 

ABSTRACT

 

The purpose of this research was to introduce and evaluate natural excipients (soy polysaccharides, CP) that have versatile property in the orally disintegrating tablets. The main objective of this work was to assess the excipient for its activity as a disintegrant and compare its properties with other synthetic superdisintegrants. Orodispersible tablets containing a model drug, Lornoxicam was prepared using different ratios of banana powder, soy polysaccharides, crosspovidone, croscarmellose sodium (CCS) and sodium starch glycollate (SSG) as disintegrants. The prepared tablets were evaluated for their physiochemical properties like wetting time, water absorption ratio, dispersion time, disintegration time and drug release studies. It was observed that the results obtained from formulations containing the soy polysaccharides and CP as superdisintegrant showed a better profile in comparison to banana powder, CCS and SSG. Disintegration time of the formulations varied from 15 to 36s for all the formulations. Dissolution studies suggested that the drug dissolution from formulations containing soy polysaccharides was more than 90% within 15min in comparison to 82% and 85% for CCS and SSG respectively. Stability studies of the prepared tablets showed non-significant drug loss and drug release. Hence, it was concluded that banana powder can be used as a natural disintegrant in orodispersible tablets. The excipient being available naturally and having nutritional benefits adds value to the formulation and can be utilized as an effective excipient in preparing tablets with less cost.

Keywords: Orodispersible tablet, soy polysaccharides, banana powder, dispersion time, dissolution studies.


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