Mon, 20 Nov 2017

Synthesis and Biological Evaluation of Amino acid Derivatives of Salicylic Acid As Analgesic and Anti-inflammatory Agents

 

Kamlesh. R. Ahire*1, Sampada. S. Jangam1 , Rishikesh. V. Antre1, Prafulla P. Adkar1, Hemlata M. Nimje1,

1. JSPM’S Charak College of Pharmacy and Research, Wagholi, Pune-412 207, India


 

ABSTRACT

Inflammation is a complex biological response of vascular tissues to harmful stimuli. The stimulus may be thermal (heat or cold), chemical (foreign substances, foreign organisms, drugs), or mechanical (trauma). Anti-inflammatory agents are the agents which relieves the inflammation. Amino acids L-tyrosine was refluxed in presence of thionyl chloride and methanol for 8 hrs to form its methyl ester hydrochloride(a). Compound (a) and taurine were refluxed with Salicylic acid in 30 % NaOH solution for 2 hrs and neutralized with conc. hydrochloric acid to precipitate target compounds (b, c). These compounds were characterized on basis of melting point, TLC (Rf value), IR and 1H NMR spectra and evaluated for analgesic and anti-inflammatory activity. Target compound (b) was found to be most active with 96.3 % protection for analgesic and anti-inflammatory activity.

Keywords: Salicylic acid, Amino acids, Analgesic, Anti-inflammatory.


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