Sat, 18 Nov 2017

Synthesis of Some Novel Triazole Heterocyclic Derivatives as Antibacterial Agents

 

Monika Kakadiya*1, Bharti Parmar, Chethan GH.3Satyendra Deka3, J. Saravanan3S. Mohan

1., N.R Vekaria Institute of Pharmacy, C. L. College Campus, Junagadh, Gujarat, India.

2.Department of Pharmaceutical Science, Saurastra University, Rajkot, Gujarat, India.

3.PES College of Pharmacy, Bangalore-560050,Karnataka, India.

 


ABSTRACT

4-(4′-chlorophenyl)-thiazol-2-carbohydrazide(2) obtained from Ethyl-4-(4′-chloro phenyl)-thiazol-2-carboxylate(1) by the treatment with hydrazine hydrate. The synthesis of Potassium-[4-(4′-chlorophenyl)-thiazol]-2-dithiocarbazinate(3) was performed from reaction of 2 with alcoholic potassium hydroxide and carbon disulphide. Moreover 4-amino-5-(4′-(4′′-chlorophenyl)thiazol-2′-yl)-3-mercapto-4H-1,2,4-triazole(4) were obtained by refluxed in the presence of compound 3 and hydrazine hydrate with water. The condensation of 4 with substituted aromatic aldehydes generated the corresponding different triazole Derivatives (5a-m). The structures of the compounds were confirmed by elemental analysis and spectral analysis. Antibacterial activity of the synthesized compounds was evaluated by tube dilution method against two gram positive and two gram negative bacteria using ciprofloxacin as standard.

Keywords: Synthesis, Triazoles, Anti bacterial activity


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