Sat, 18 Nov 2017

Development and Validation of UV Spectrophotometric Method for Simultaneous Estimation of Pantoprazole and Levosulpiride in Pharmaceutical Dosage form

 

Sahdev Chosla*1, Vishal Bhatt1, Hiren Kadikar1

1.Department of Quality Assurance, Arihant School of Pharmacy & BRI, Adalaj, Gandhinagar, Gujarat, India


 

ABSTRACT

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical derivative spectroscopic method for the simultaneous determination of Pantoprazole and Levosulpiride in pharmaceutical dosage form. In this study a first-derivative spectroscopic method was used for simultaneous determination of pantoprazole and levosulpiride using the zero-crossing technique. The measurements were carried out at wavelengths of 269 and 249 nm for Pantoprazole and Levosulpiride respectively. The method was found to be linear (r2>0.9929) in the range of 10-50 μg/ml for Pantoprazole at 269 (ZCP of Levosulpiride) nm. The linear correlation was obtained (r2>0.9948) in the range of 10-50 μg/ml for Levosulpiride at 249 (ZCP of Pantoprazole) nm. The limit of determination was 0.69 and 0.58 μg/ml for pantoprazole and levosulpiride respectively. The limit of quantification was 2.06 and 1.69 μg/ml. The method was successfully applied for simultaneous determination of Pantoprazole and Levosulpiride in pharmaceutical dosage form.

Keywords: Pantoprazole, Levosulpiride, Derivative spectroscopic method, Zero-crossing point.


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