DOI: 10.21276/ajptr
Fri, 19 Apr 2019

Development and Validation of Analytical Methods for Simultaneous Estimation of Cefixime and Levofloxacin in Pharmaceutical Dosage form


Vishal Bhatt*1, Chosala Sahdev1, Darji Suresh1, Hiren Kadikar1

1.Arihant school of pharmacy & BRI, uvarsad square,S. G. Highway, Adalaj, Dist. Gandhinagar-382421, Gujarat



Accurate, precise, rapid and economical first order derivative spectroscopic method was developed and validated for the estimation of Cefixime and levofloxacin in tablet. The wavelengths selected for quantitation were 289.45 nm for levofloxacin (zero cross for cefixime) and 317.0 nm for cefixime (zero cross for levofloxacin). Linearity for detector response was observed in the concentration range of 2-12 μg/ml for both Cefixime and Levofloxacin using methanol as a solvent with correlation coefficient 0.991 and 0.993 respectively. The proposed method was successfully applied for the simultaneous estimation of both drugs in tablet.

Keywords: Cefixime, levofloxacin, UV specroscopy, method validation, tablet

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