Sat, 18 Nov 2017

Spectrophotometric Method for Simultaneous Estimation of Eperisone Hydrochloride and Aceclofenac Sodium in Synthetic Mixture

 

Paresh U Patel1, Bhumi H. Barot 1*

1. Department of Pharmaceutical Analysis, Center for Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.

 


 

ABSTRACT

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Eperisone hydrochloride and Aceclofenac sodium in mixture. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Eperisone hydrochloride has absorbance maxima at 255 nm and Aceclofenac sodium has absorbance maxima at 275 nm in methanol. The linearity was obtained in the concentration range of 4-20 μg/ml and 4-20 μg/ml for Eperisone hydrochloride and Aceclofenac sodium, respectively. The concentrations of both drugs in synthetic mixture were determined by using simultaneous equations. The mean recovery was 100.34 ± 0.27 and 100.64 ± 0.71 for Eperisone hydrochloride and Aceclofenac sodium, respectively. The method was applied for the determination of these drugs in mixture. The suitability of this method for the quantitative determination of Eperisone hydrochloride and Aceclofenac sodium was proved by evaluating different validation parameters. The proposed method was found to be simple and sensitive for the routine estimation of these drugs in combination. The results of analysis have been validated statistically and by recovery studies.  

Keywords: Eperisone hydrochloride, Aceclofenac sodium, Recovery, Simultaneous equations method, Validation.

 


[PDF]  Viewed: 1178  Downloaded: 124
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter