Sat, 18 Nov 2017

Comparative Study of Various Permeation Enhancers for Development of Sumatriptan Succinate Buccal Tablet

 

Amarjit P. Rajput*1, Vikas P. Patil1, Swapnil P. Chaudhari, Dheeraj T. Baviskar1

1. Department of Pharmaceutics, Institute of Pharmaceutical Education, Boradi- 425405, Dist- Dhule, Maharashtra, India.


 

ABSTRACT

The aim of the present study was to prepare buccoadhesive sustained release tablets of sumatriptan succinate using various permeation enhancers to release the drug for extended period of time with reduction in dosing frequency. In the present work sumatriptan succinate was used as a model drug and interaction studies performed using FTIR spectroscopy and DSC revealed that there was no drug, polymer and permeation enhancer interaction. Fulvic acid was extracted from shilajit by using resins. Fulvic acid was characterized by various spectroscopic techniques. Buccoadhesive sustained release tablets of sumatriptan succinate with various permeation enhancers were prepared by direct compression method using bioadhesive polymers like Carbopol 934 and HPMC K100M. The physical characteristics like surface pH, swelling index, in vitro mucoadhesion time, in vitro mucoadhesion strength, in vitro drug release study and in vitro permeation study. The in vitro release study showed 99.88%, 99% and 99.40% of drug release with fulvic acid, chitosan and beta cyclodextrin respectively. The permeation study showed 90%, 82% and 78% of drug permeated with fulvic acid, chitosan and beta cyclodextrin respectively. Sumatriptan succinate release from the buccoadhesive system was extended and exhibited a non fickian drug release kinetics approaching to first order as the values of release rate exponent varied between 0. 97 to 0.99 resulting in a regulated and complete release until 8 hours.

Keywords: - Buccal drug delivery system, Sumatriptan succinate, Fulvic acid, In-vitro drug release study, In-vitro permeation study.


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