Sat, 18 Nov 2017

A Validated RP-HPLC Method for the Estimation of Telmisartan in Tablet Dosage forms

 

J.V.L.N. Seshagiri Rao1*, Vemula Vijayasree2, Chinnaiah Palavan2

1. Yalamarty College of Pharmacy, Visakhapatnam.

2. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam.


 

ABSTRACT

An accurate, precise and reproducible high performance liquid chromatographic method was developed for quantitative estimation of telmisartan in bulk drug samples and tablet dosage forms. Chromatographic separation of the drug was achieved on a Kromasil C18 column (150 x 4.6 mm; 5µ) using a mixture of phosphate buffer (pH 4.0) and acetonitrile (40:60 v/v) as the mobile phase at a flow rate of 1.0 mL/min. Under optimized conditions, the retention time of the drug was found to be 2.887 min. Good detecting sensitivity for the analyte was observed at 224 nm. The quantitation calibration curve for the drug was linear over the range of 20-60 µg/mL. The performance of the proposed method was validated as per ICH guidelines. The method was proved to be suitable for the estimation of telmisartan in tablet dosage forms.

Key words: Telmisartan, Estimation, Tablets, HPLC.


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