Sat, 18 Nov 2017

Novel 1, 2, 3, 5, 6-Thiatetraazepine; their Synthesis, Antibacterial, Antifungal Studies and their Isomerisation into 1, 2, 3, 5, 6-Pentaazepine

 

P. S. Ingole1*, V. R. Tembhare2, C. S. Bhaskar2, B. N. Berad3

1.P.G. Department of Chemistry, Shri Shivaji Science College, Amravati – 444 603

2.Department of Chemistry, Art’s, Commerce & Science College, Koradi – 441111

3.Department of Chemistry, RTM, Nagpur University,Nagpur – 440033


 

ABSTRACT

2 (H/substituted)-4-aryl-5H,6H, 7-arylimino-1,2,3,5,6-thiatetraazepines (6) have been obtained by basification of 2-(H/substituted)-4-aryl-5H,6H-7-arylmino-1,2,3,5,6-thiatetraazepine monohydrochloride (5).  The latter were synthesized by the interaction of N-aryl-S-chloro isothiocarbamoyl chloride (4) and 1-(H / substituted)-3-aryl-dihydroformazan (3), which were prepared initially by the condensation of aryl acid hydrazide (1) and hydrazine hydrate or substituted hydrazine (2). Compound (6) on benzoylation with benzoyl chloride and excess 10 % sodium hydroxide solution afforded benzoyl derivatives (7) and on boiling with aqueous ethanolic sodium hydroxide solution isomerizes into corresponding 1, 2, 3, 5, 6-pentaazepines (8).  The structures of all the synthesized compounds were established on the basis of elemental analysis, equivalent weight determination, spectral analysis like IR, 1H-NMR and Mass.  These newly synthesized compounds (6) were screened for their antifungal and antibacterial activity.

Keywords: Synthesis, 1, 2, 3, 5, 6-thiatetraazepine, antibacterial antifungal activity, isomerisation into 1, 2, 3, 5, 6-pentaazepine.


[PDF]  Viewed: 876  Downloaded: 113
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter