Sat, 18 Nov 2017

Spectrophotometric Estimation of Tramadol Hydrochloride and Aceclofenac in Combined Dosage form by Second Order Derivative Method

Trupti. P. Patel1*, Arun. M. Prajapati1


1.Department of Pharmaceutical Analysis, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.


 

ABSTRACT

The present manuscript describes sensitive, rapid, accurate, and precise second order derivative spectrophotometry method for the simultaneous determination of tramadol hydrochloride and aceclofenac in combined dosage form. The absorbance values at 225 nm and 215 nm of second derivative spectrum was used for the estimation of tramadol hydrochloride and aceclofenac in combined dosage form, respectively without mutual interference. This method obeyed beer’s law in the concentration range of 5-80μg/ml and 4-28μg/ml for tramadol hydrochloride and aceclofenac respectively. The method was successfully applied to combined dosage form because no interference from the excipients was found. The suitability of this method for the quantitative determination of tramadol hydrochloride and aceclofenac was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of tramadol hydrochloride and aceclofenac in combined dosage form. The results of analysis have been validated by recovery studies.

Keywords tramadol hydrochloride, aceclofenac, second order derivative spectrophotometry method.


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