DOI: 10.21276/ajptr
Fri, 19 Apr 2019

In vitro Comparative study of Venlafaxine Hydrochloride Sustained Release Formulation using different Lipidic Matrices Prepared by Melt Granulation Technique.


Gaurav S. Yeola1, Dnyanesh B. Shelar1, Pravin D. Chaudhari*1

1.Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune- 411018, Maharashtra, India.



The objective of this study was to investigate hydrogenated vegetable oil (Lubritab) and hydrogenated castor oil (HCO) as potential lipophilic binders in melt granulation process for the preparation of sustained release matrices of venlafaxine hydrochloride, a highly water soluble drug. The effect of concentration, type of polymer and method of preparation (direct compression of physical mixtures and melt granulation technique) were studied. Granules prepared by melt granulation method were evaluated for micromeritic properties, FT-IR, DSC, XRD and SEM. The compressed tablets were subjected to thickness, hardness, friability, mass variation test, drug content and in vitro release studies. The result of dissolution study showed that formulations containing drug: HCO (1:3 m/m) retarded drug release more than those containing drug: Lubritab (1:3 m/m) ratio. In conclusion, melt granulation technique was found to be more appropriate in retarding the release compared to compression of physical mixtures of drug and lipophilic binder. The study showed that HCO and Lubritab are the appropriate meltable binders that can be utilized as matrix-forming agent to sustained the release of highly water soluble drugs.

Keywords: sustained release, melt granulation, hydrogenated castor oil, hydrogenated vegetable oil

[PDF]   Viewed: 1853   Downloaded: 273
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter