Mon, 20 Nov 2017

NSAID Microemulsion In Treatment of Rheumatoid Arthritis

Peyush Singh1*, C.S.Chauhan1, R.K.Kamble1, A.Sen2

1.Bhupal Nobels’ College of Pharmacy, Udaipur, Rajasthan, India


ABSTRACT

Rheumatoid arthritis is a common inflammatory disease characterized by progressive bone and cartilage destruction, A full cure for rheumatoid arthritis  is yet to be discovered but  Microemulsion containing NSAID can be used as best option for the management of pain in Rheumatoid arthritis because of their potential to incorporate a wide range of drug molecules (hydrophilic and hydrophobic) due to the presence of both lipophilic and hydrophilic domains.  Association of drugs with Microemulsion is normally noncovalent, based on collective strength of weak binding forces which are broken to release drug. The small droplets of Microemolsion provide better adherence to membranes and transport NSAID molecules in a controlled fashion for the pain management of Rheumatoid Arthritis. These adaptable delivery systems provide protection against oxidation, enzymatic hydrolysis and improve the solubilization of lipophilic drugs and hence enhance their bioavailability.

Keywords: Rheumatoid arthritis, Microemulsion, NSAID, Lipophilic domain,  Hydrophilic domains.


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