Mon, 20 Nov 2017

Recent Advancements In Site Specific Mucoadhesive Drug Delivery Systems and Polymers

    Sunena Jha*1, Nanda Arun2

1. Dept. of Pharmaceutical Sciences Guru Jambheshwar University of Science and Technology, Hissar, Haryana (India)

2. Deptt. of Pharmaceutical Sciences Maharshi Dayanand University, Rohtak, Haryana (India)


ABSTRACT

Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for better therapeutic results. Mucoadhesive drug delivery systems are used to prolong the residence time of the dosage form at the site of application or absorption and to facilitate intimate contact of the dosage form with the underlying absorption surface to improve and enhance the bioavailability of drug. Some of the promising plymers that have been commonly used in these systems include polycarbophil, carbopol, lectins, chitosan, carboxymethylcellulose, pectin, carragenan, alginic acid, polylysine, polybrene, polyethylene glycol, polyvinyl pyrrolidone , dextran etc. Now  scientists are developing mucoadhesive micro and nanoparticulate systems by using  novel mucoadhesive polymers for better therapeutic results and site specific targeting with lesser side effects. Improvements in mucoadhesive based oral delivery and, in particular, the development of novel, highly-effective and mucosa-compatible polymers, are creating new commercial and clinical opportunities for delivery of narrow absorption window drugs at the target site to maximize their efficacy. This review is an effort to provide information on such mucoadhesive drug delivery systems that are developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effect.

Keywords: Mucoadhesive; gastroretentive; bioavailability; micro and nanoparticulte; polymers.


[PDF]  Viewed: 1083  Downloaded: 157
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter