DOI: 10.21276/ajptr
Tue, 25 Jun 2019

A Review: Screening Models for Wound Healing Activity in Animals

Mitali Shrimanker*1, Natavarbhai Patel2, Hiral Modi 3, Riddhi Dave3

1.Research scholar of Hemchandracharya North Gujarat University, Patan, Gujarat

2.Shri B. M. Shah Pharmaceutical Education & Research, Modasa, Gujarat

3.Saraswati Institute of Pharmaceutical Sciences, Gandhinagar, Gujarat


Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. A wound can be described as a defect or a break in the skin, resulting from physical or thermal damage or as a result of the presence of an underlying medical or physiological condition. Wound healing is a complex process of cellular and biochemical interactions involving various cells such as keratinocytes, fibroblasts and endothelial cells. The in vitro assays & in vivo models can be performed to evaluate wound healing activity. In vitro models are useful, quick, and relatively inexpensive. In vivo-Small animals provide a multitude of model choices for various human wound conditions. In vitro fibroblast assay, keratinocytes assay can be performed. The wound healing efficacies of various herbal extracts have been evaluated by In vivo- models  excision models, incision models, dead space models, burn modes can be performed on small animals after getting approval from the Ethics committee. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts. Wound healing property can be checked by measuring tensile strength of skin, measurement of wound area, percentage of contraction, collagen content, protein estimation, Period of epithilazation.

Key words: In vitro cell assays, excision models, burn wound models, incision models, dead space models

[PDF]   Viewed: 5334   Downloaded: 932
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter