Mon, 20 Nov 2017

Piroxicam Solid Lipid Microparticles: In vitro and in vivo Evaluation

NC Obitte1*, SA Chime1, DC Ibe2, OR Nweke1, TC Ugwudah1.

1.Department of Pharmaceutical Technology and Industrial Pharmacy, University of        Nigeria, Nsukka 410001, Nigeria

2. Department of Public Health, Federal University of Technology, Owerri, Nigeria.


ABSTRACT

The aim of this work was to investigate the potential of solid lipid microparticles (SLM) to offer gastroprotection and improve piroxicam’s anti-inflammatory property. The effects of NaCl and cabosil® on the properties of the SLM were also evaluated. The SLM were prepared by the hot homogenization technique using Ultra turrax (T25 Basic digital). Phospholipon® 90G and Capra hircus fat constituted the lipid matrix. The particle size, drug content, encapsulation efficiency, in vitro drug release, anti-inflammatory and ulcerogenic studies were carried out on the formulations. Results showed that carbosil® significantly (p<0.05) contributed to increase in particle size of the SLM. Drug-load caused significant (p<0.05) decrease in EE % whereas significant (p<0.05) increase in EE % was associated with carbosil®. Significant (p<0.05) reduction in drug release rate was occasioned by carbosil®. SLM batches did not show any presence of ulcer lesions and indicated satisfactory antiinflammatory property of piroxicam. In conclusion piroxicam SLM promoted gastroprotection and satisfactory antiinflammatiory activity of piroxicam.

Keywords: Solid lipid microparticles; Piroxicam; Ulcerogenicity; Anti-inflammation.


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