Mon, 20 Nov 2017

Synthesis, Characterization of Novel E-3- (Phenyl)-2-(Phenyl) Prop-2-Enoic Acid Derivatives

Nilesh Jain*1, Sarita Singhal1, Surendra Kumar Jain2

1.Mahatma Jyoti Rao Phoole University, NH-8 near Achrol, Jaipur, Rajasthan, India-302019

2.Sagar Institute of Research & Technology-Pharmacy, Ayodhya Bypass Road Bhopal, MP, India-462041


ABSTRACT

A series of novel E-3- (phenyl)-2-(phenyl) prop-2-enoic acid derivatives (1a-1h and 2a-2e) have been synthesized by the base-catalyzed condensation of phenylacetic acids (1) with aryl aldehyde in the presence of triethylamine gave the series of E-3- (phenyl)-2-(phenyl) prop-2-enoic acid (1a-1h). Reaction of thionyl chloride with the E-3- (phenyl)-2-(phenyl) prop-2-enoic acid in benzene under refluxing gave the corresponding acid chlorides, which on subsequent reaction with appropriate amines, and (dialky1amino) ethanol gave compounds 2a-2e the yield of compound was found to be in the range of 60-85%.The synthesized compounds were characterized by their physiochemical properties like solubility, melting point, IR spectroscopy, 1H NMR spectroscopy, Fab MASS and elemental analysis.

Keywords: Phenyl acetic acid, Amines, Thionyl chloride, Dialkylamino 


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