Mon, 20 Nov 2017

Impact of Concentration of Superdisintegrant on the Disintegration Time of Film Coated Tablets of Nateglinide

S R Vispute1*, R K Kamble1, C S Chauhan1

1. Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, India


ABSTRACT

Nateglinide is an insulin secretogogues, meglitinide anti-diabetic drug used for the treatment of type II Diabetes mellitus. Film coated means 2% coating immediate release tablets. Superdisintegrants used for the formulation of immediate release tablets to decrease the disintegration time of tablets and disaggregate the granules into fines. Current investigation aims to access the impact of gradient concentration of sodium starch glycolate, Crosscarmellose sodium on the disintegration time also drug release rate of tablets. The drug-excipients interaction study was carried out by Fourier Transform Infra-red and Different Scanning Calorimeter. The six formulations were formulated by using 2, 4, 6 % concentration of Superdisintegrants. The hardness of each formulation was in between 100 to 140 N. The disintegration time of formulation containing 6% (F-6), 4% (F-5) and 2 % (F-4) concentration of Crosscarmellose sodium was about 7.0, 6.0 and 3.0 min respectively. The formulation having sodium starch glycolate concentration of 2% (F-1), 4% (F-2), 6% (F-3) about 8.0, 6.0 and 4.0 min respectively. As the concentration of Superdisintegrants get on increase the disintegration time was decrease. The formulation containing sodium starch glycolate had more disintegration time than Crosscarmellose sodium containing tablets.

Keywords: Secretogogues, Diabetes mellitus, Superdisintegrants.


[PDF]  Viewed: 1231  Downloaded: 140
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter