DOI: 10.21276/ajptr
Thu, 23 May 2019

Impact of Concentration of Superdisintegrant on the Disintegration Time of Film Coated Tablets of Nateglinide

S R Vispute1*, R K Kamble1, C S Chauhan1

1. Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, India


Nateglinide is an insulin secretogogues, meglitinide anti-diabetic drug used for the treatment of type II Diabetes mellitus. Film coated means 2% coating immediate release tablets. Superdisintegrants used for the formulation of immediate release tablets to decrease the disintegration time of tablets and disaggregate the granules into fines. Current investigation aims to access the impact of gradient concentration of sodium starch glycolate, Crosscarmellose sodium on the disintegration time also drug release rate of tablets. The drug-excipients interaction study was carried out by Fourier Transform Infra-red and Different Scanning Calorimeter. The six formulations were formulated by using 2, 4, 6 % concentration of Superdisintegrants. The hardness of each formulation was in between 100 to 140 N. The disintegration time of formulation containing 6% (F-6), 4% (F-5) and 2 % (F-4) concentration of Crosscarmellose sodium was about 7.0, 6.0 and 3.0 min respectively. The formulation having sodium starch glycolate concentration of 2% (F-1), 4% (F-2), 6% (F-3) about 8.0, 6.0 and 4.0 min respectively. As the concentration of Superdisintegrants get on increase the disintegration time was decrease. The formulation containing sodium starch glycolate had more disintegration time than Crosscarmellose sodium containing tablets.

Keywords: Secretogogues, Diabetes mellitus, Superdisintegrants.

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