Mon, 20 Nov 2017

Spectral Investigation, Structural Assignments and Anti-Tumor Activities of Pyrimidine Based Transition Metal (Ii) Complexes

*M. Umadevi1,2, *A. Ramu1, V. Muthuraj3, P. Saravana bhava4

1.Department of Inorganic Chemistry, School of Chemistry, Madurai KamarajUniversity, Madurai – 21, Tamilnadu, India

2. Department of Chemistry, Nehru Memorial College, Puthanampatti,iruchirappalli,Tamilnadu, India - 621 007.

3. Department of Chemistry, V.H.N.S.N.College, Virudhunagar,Tamilnadu, India- 626 001.

4. Department of Chemistry,S.Vellaichamy NadarPolytechincCollege, Virudhunagar,Tamilnadu, India.


ABSTRACT

Three novel Mannich bases 5-[(4-chlorophenyl)-(4-methylpiperazin-1-yl)-methyl]-pyrimidine-2,4,6-trione :CBzBAPz(NM), 5-[(4-nitrophenyl)-(4-methylpiperazin-1-yl)-methyl]-pyrimidine-2,4,6-trione: NBzBAPz(NM) and 5-[(phenyl)-(4-methylpiperazin-1-yl)-methyl]-pyrimidine-2,4,6-trione: BzBAPz(NM) are prepared by the condensation of N-methyl piperazine with p-chlorobenzaldehyde / p-nitro benzaldehyde / benzaldehyde and barbituric acid and  characterized by physico-chemical,  spectroscopic, and powder X-ray diffraction studies. Further, Cu (II), Cd (II) and Pd (II) complexes of titled ligands are synthesized and characterized. Based on the experimental results, the chelating (bidentate) behavior of the ligands is accessed. The X-band e.p.r.spectrum, electrochemical studies of the Cu (II) complex have been carried out and discussed. Three novel Mannich bases and their complexes exhibit comparable potential cytotoxicity against breast cancer cell line (MCF-7), particularly, strong cytotoxicity is observed in the case of palladium. Morphological features of cells used for the study is photographed. Use of fluorochromesacridine orange and ethidium bromide reveals apoptotic morphological features.

Keywords: barbiturates, N-methyl piperazine, anticancer activity, Mannich bases, MTT assay.

 


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