Mon, 20 Nov 2017

Formulation and Evaluation of Pantoprazole and Domperidone Mouth Dissolving Tablet Using Different Superdisintegrants

T.Mallamma*1, Snehalatha1, T.S.Nagaraja1, T.Vyjayanthimala1.

1. S.J.M.College of Pharmacy,Chitradurga, Karnataka.


ABSTRACT

The purpose of this research was to develop mouth dissolve tablets ofdomperidone andpantoprazole, were prepared by direct compression technique. Pantoprazole inhabits gastric acid formation and thereby it is very efficient for the treatment of gastric and duodenum ulcers. Domperidone, an antiemetic drug, has been used as an add-on treatment in adults and children. The tablets were prepared using microcrystalline cellulose as diluent and  aspartames as sweetening agent along with three different levels of disintegrant. The superdisintegrant used in this study were CCS and SSG. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. formulation prepared with 30% of CCS showed Disintegration time of 20seconds in vitro. Also the hardness, friability, dissolution rate of prepared tablets (batch F6) were found to be acceptable according to standard limits.

Keywords: pantoprazole, Domperidone, Superdisintegrants, melt in mouth tablet, Direct compression.


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