Mon, 20 Nov 2017

Synthesis, Spectral Characterization, Antimicrobial Screening and DNA Studies of Transition metal complexes of Cu(II), Co(II), Ni(ii) and Zn(II) with Heterocyclic Triazol based derivative

P.Saravana Bhava1*, P.Tharmaraj2, V.Muthuraj3 , M. Umadevi 4

1.Department of Chemistry, S.Vellaichamy Nadar Polytechinc College, Virudhunagar, India.

2.Department of Chemistry, Thiagarajar College, Madurai, India.

3.Research Department of Chemistry, VHNSN College, Virudhunagar, India.

4. PG & Research Department of Chemistry, Nehru Memorial College, Puthanampatti, Tiruchirappalli, Tamilnadu, India.


ABSTRACT

A new series transition metal complexes of Cu(II), Co(II), Ni(II) and Zn(II)  complexes have been synthesized from 2-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)phenol (AMPT). The nature of bonding and the geometry of the complexes have been deduced from elemental analyses, magnetic susceptibility, infrared, electronic, 1H NMR, 13C NMR, and EPR spectral studies. The redox behavior of copper complexes was studied by cyclic voltammetry.  The second harmonic generation (SHG) efficiency was measured by Kurtz and Perry method. The ligand and their metal complexes were screened by Well diffusion method. The interaction of complexes with CT- DNA was investigated by viscosity measurement. Results suggest that all the complexes bind to DNA via an intercalative mode. The DNA cleavage ability of all the complexes was examined on calf thymus (CT-DNA) plasmids using gel electrophoresis experiment in presence of H2O2. From the results it is concluded that all the complexes cleave DNA.

Keywords: 1,2,4-Triazoles, Metal complexes, SGH,  Antibacterial activity, DNA cleavage. 


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