Mon, 20 Nov 2017

Formulation and In Vitro Evaluation of Immediate Release Tablet of Fexofenadine Hydrochloride.

Ujwala R. Bagmar*1, Pankaj S. Jadhav1, Amit S. Lunkad1, Shital G. Uttarwar2, Sampada S. Jangam3.

1. SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune, Maharashtra, India.

2. Sudhakarrao Naik Institute of Pharmacy, Pusad, Yawatmal, Maharashtra, India.

3. JSPM’s Charak College of Pharmacy, Wagholi, Pune, Maharashtra, India


ABSTRACT

The pivotal motif of the present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL may be increased by using superdisintegrant in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using lactose, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablet were prepared and evaluated for Hardness, friability, weight variation, content uniformity, wetting time, disintegration time and in-vitro drug release. Disintegration time decreased with increase in the level of crospovidone. Whereas, disintegration time increased with increase in the level of sodium starch glycolate. The results indicate that the selected batch of tablet formulation containing crospovidone provides DT between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis


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