DOI: 10.21276/ajptr
Thu, 23 May 2019

Development & Validation of Simultaneous Equation Spectrophotometric Method for Estimation of Flupentixol & Melitracen in Combined Dosage Form

Komal Patel1, Sellapan Mohan2

1 Research Scholar JJT University, Jhunjhunu, Rajasthan- 333001

2 Saraswati Institute Of Pharmaceutical Sciences, Gandhinagar- 382355, India


A simple, accurate, precise, reproducible and economical UV spectroscopic methods for simultaneous estimation of Flupentixol and Melitracen in tablet dosage form have been developed. simultaneous equation method employs formation and solving of mathematical simultaneous equation using 254 nm and 230 nm as the λmax of Melitracen and Flupentixol respectively in 0.1N HCl. These methods were validated as per ICH norms. Calibration curves were linear over the concentration ranges of 1-10 μg/ml for Flupentixol and 10-100 μg/ml for Melitracen with mean recovery of 100.71 ± 1.53 & 100.36 ± 0.66 for Flupentixol & Melitracen respectively by Simultaneous Equation method. The validation study is statistically significant as all the statistical parameters are within the acceptance range (% RSD < 2.0 and S.D. < 2.0) for both accuracy and precision. The methods are successfully applied to pharmaceutical formulation, with no interference from excipients as indicated by the recovery study. The proposed methods are simple, rapid, economic and accurate for routine simultaneous estimation of Flupentixol and Melitracen.

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