DOI: 10.21276/ajptr
Thu, 23 May 2019

Development and Validation of Simultaneous Equation Method for Simultaneous Estimation of Amlodipine Besylate and Indapamide in Combined Dosage Form

Shweta Bhadani1*, Mohan Sellappan2

1.Research Scholar, JJT University, Jhunjhunu, Rajasthan, India.

2.Saraswati Institute of Pharmaceutical Sciences, Dhanap, Ghandhinagar-382355, Gujarat, India.


The manuscript describes validated simultaneous equation method for the simultaneous estimation of Amlodipine Besylate and Indapamide in combined dosage form. Simultaneous equation method was based on the estimation of both the drugs at two wavelengths i.e. absorption maxima of both drugs. An absorption maxima of Amlodipine besylate was 240 nm and absorption maxima of Indapamide was 215 nm in methanol. The linearity was obtained over the concentration range of 10 – 30 µg/mL for amlodipine besylate and 2 – 10 µg/mL for Indapamide with mean recovery of 99.45 ± 0.84 % and 99.46 ± 0.33 % for Amlodipine Besylate and Indapamide, respectively. These methods were found to be simple, sensitive, accurate, precise and economical and applicable for the simultaneous determination of Amlodipine Besylate and Indapamide in combined dosage form.

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