DOI: 10.21276/ajptr
Thu, 23 May 2019

Formulation and In vitro / In vivo evaluation of Sustained oral delivery system of Mefenamic acid from floating in situ gelling formulations

Nidhal Khazaal Marie1*

1. College of Pharmacy, University of Al-Mustansiriya, Baghdad-Iraq


The aim of this work is to prepare oral liquid formulation of the non-steroidal anti-inflammatory drug mefenamic acid with sustained release property using floating in situ gelling technique. Gellan gum and sodium alginate separately were used to form the gels. Results showed the release from gellan gum was slower than that from sodium alginate in concentration dependent manner; where the drug release decreased as the amount of the gelling agent increased. Results showed that increasing the concentration of gellan gum (0.25,0.5 and 1%w/v) caused a decrease in gelation time and floating lag time with floating duration for more than 8 hours and significant decrease (p<0.05) in drug release. Increasing the concentration of sodium alginate (1, 1.5 and 2%w/v) also results in significant decrease (p<0.05) in gelation time, floating lag time and drug release with long floating duration. On the other hand increasing gas generating agent calcium carbonate (0.5, 1 and 1.5%w/v) reduces significantly floating lag time and drug release but no significant effect on gelation time. Increasing drug loading showed significant increase in drug release. Sorbitol 5%w/v was added to the selected formula as sweetening agent, which leads to decrease in the viscosity with no significant effect on drug release. Overall results indicate that drug release followed diffusion control mechanism, and were used for optimizing the liquid formulation of mefenamic acid with sustained release property, minimizing side effects and improving the bioavailability as which may reduce the dose and dosing rate with optimum effectiveness.

[PDF]   Viewed: 1666   Downloaded: 211
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter