Tue, 21 Nov 2017

PLGA Based Nanoparticle:Best tool for Treatment of Visceral Leishmaniasis

Vaibhav Prakash Srivastava*1, Shaundarya Kumar2, Smriti Ojha Tripathi1,

1 Vishveshwarya Institute of Medical Science, G.B.Nagar.Uttar Pradesh,India

2 Kamala Nehru Institute of Technology & Management, Faridipur, Sultanpur U.P. India.


ABSTRACT

Some of the natural macromolecules have been used to prepare NPs. These polymers include gelatin, alginate, chitosan and PLGA. They are hydrophilic natural polymers and have been used to synthesize biodegradable NPs by various method. Numerous techniques now exist for synthesizing different set of nanoparticles based on the type of drugs used, and the targeted organ and delivery mechanism selected. Depending upon the protocol of choice, the parameters can be tailored to create the best possible characteristics for the nanoparticles. In this manuscript we have reviewed a number of biodegradable nanoparticles currently in use, and the techniques of their preparation. We will also discuss advances in surface modifications, drug encapsulation and specific end applications of various types of NPs. Nanotechnology, although not a new concept, has gained significant momentum in recent years. Due to the recent advances in material science and nano-engineering in the last decade, the nanoparticles have become very attractive for their applications in the fields of biology and medicine. Nanostructured materials are materials with sizes in the 1-100 nm range, which demonstrate unique properties and functions due to their "size effect".Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body.

Keyword: PLGA Nanoparticles, Method & Characterization, Visceral Leishmaniasis


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