Thu, 23 Nov 2017

A Systematic Review of Semicarbazones as an Anticonvulsant Agent

Mehnaz Kamal1,*, Talha Jawaid 2

1 Faculty of Pharmacy, Integral University, Lucknow (U. P.), India-226026

2 Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow (U. P.), India-226002


ABSTRACT

Anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. The goal of an anticonvulsant is to suppress the rapid and excessive firing of neurons that start a seizure. The use of current antiepileptic drugs has been questioned due to the non selectivity of the drugs and the undesirable side effects posed by them. This lead to the search for antiepileptic compounds with more selective activity and lower toxicity continues to be an area of investigation in medicinal chemistry. Semicarbazones are compounds which are synthesized by the condensation of semicarbazide and aldehydes/ketones. The literature survey revealed that semicarbazones had been emerged as a compound with broad range of activities including anticonvulsant, antitubercular, anticancer and antimicrobial activity. In this review chemistry and anticonvulsant activity of semicarbazone analogues are discussed.

Keywords: anticonvulsants, semicarbazones, chemistry, review


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