Thu, 23 Nov 2017

Design Development and Evaluation of Fast Dissolving Tablets of Loratadine by Direct Compression Method

Arpit Shaileshkumar Pandya*1, Shashank Nayak N1, Shwetha S Kamath K2, Dhaval M Raulji, A R Shabaraya

1. Srinivas college of Pharmacy, Valachil Mangalore-574143


ABSTRACT

Fast dissolving tablets are the tablets which dissolves rapidly and shows higher bioavailability than conventional tablets. The concept of formulating Fast dissolving tablets of Loratadine (antiallergic drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of three synthetic superdisintegrants (Crosscarmeloss sodium, Sodium starch glycolate and Crospovidone). In the present work two methods of solid dispersion were compared for improving the bioavailability i.e Solvent Evaporation and Fusion method with beta cyclodextrin as a carrier to increase the solubility of the drug. Comparison between these three synthetic superdisintegrants was done by taking different ratios individually and in combination. Combination of these three superdisintegrants shows synergistic effect when it is compared to individually. Prepared tablets were subjected to different evaluation parameters such as hardness, thickness, friability, weight variation, drug content uniformity, in vitro disintegration time, wetting time, in vitro dissolution studies and stability studies are carried out by using the best formulation. From all the formulations prepared and evaluated F11 was found to the best formulation.

Key words: Fast dissolving tablets, Solid dispersion, Crosscarmeloss sodium, Sodium starch glycolate, Crospovidone, Evaluation parameters.


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