Thu, 23 Nov 2017

Effect of Natural Superdisintegrants on the Fast Dissolving Tablet of Carvedilol by Sublimation Method

Dhaval Mayursinh Raulji*1, Shwetha S. Kamath K1, Shashank Nayak N1, Arpit S Pandya2, A.R.Shabaraya3

1. Srinivas College Of Pharmacy, Valachil, Post Parengipete, Mangalore-574143


ABSTRACT

Fast dissolving tablets are the tablets which dissolves rapidly and shows higher bioavailability than conventional tablets. The concept of formulating Fast dissolving tablets of Carvedilol (antihypertensive drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two natural superdisintegrants (Hibiscus Rosa, Linseed Mucilage). In the present work solid dispersion were prepared by solvent evaporation method for improving the bioavailability with beta cyclodextrin as a carrier to increase the solubility of the drug. And after compressing the tablet , heat is applied to create pores in tablet as it contain camphor as subliming agent which increase the porosity and cause faster release of drug from the tablet. Comparison between these two natural superdisintegrants was done by taking different ratios individually and in combination. Combination of these two superdisintegrants shows synergistic effect when it is compared to individually. Prepared tablets were subjected to different evaluation parameters such as hardness, friability, weight variation, drug content uniformity, in vitro disintegration time, wetting time, in vitro dissolution studies and stability studies are carried out by using the best formulation. From all the formulations prepared and tested, F11 was found to be the best formulation.

Keywords: Fast dissolving tablets, Solid dispersion, sublimation, Hibiscus Rosa, Linseed Mucilage.


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