Tue, 21 Nov 2017

Studies of Drug-Polymer Interactions of Carvedilol with various Polymers using some Analytical Techniques

Trishna Bal*,Padala Narasimha Murthy1,Shubhranshu Sengupta2

1.Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India

2.Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Orissa.

3.Department of Horticulture, Birsa Agriculture University, Kanke, Ranchi, Jharkhand, India


ABSTRACT

The present study aims at investigating the different combinations of polymers with inclusion complex of Carvedilol (CR)-Hydroxypropyl betacyclodextrin (HPβCD) prepared in a ratio of 1:1 by use of various analytical techniques like Fourier Transformation Infrared spectroscopy (FTIR), X-ray diffraction technique (XRD), Digital scanning calorimetry (DSC), Thermo gravimetric analysis (TGA) as a part of preformulation studies. Various polymers used for the present study were Sodium alginate (SA), Hydroxy propyl beta cyclodextrin (HPBCD), Hydroxy propyl methyl cellulose LV E-15(HPMC), Pectin (P), Eudragit NE30D (EU). This study indicated that Carvedilol formed inclusion complex with the HPβCD, but in combination with other polymers, drug did not show any other interactions.

Keywords: Carvedilol, FTIR, TGA, Drug-polymer compatibility


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