Tue, 21 Nov 2017

Antiulcer Activity Aloe Vera Gel And Its Interaction With Conventionally Used Antiulcer Drug Pantoprazole In Rats

Naveen J1, Jyothi Y1*, M Somashekhar1

1.Krupanidhi College of Pharmacy, Bangalore-35, India.


ABSTRACT

 Aloe vera are widely used in the cosmetics and alternative medicine industries, being marketed as variously having rejuvenating, healing, or soothing properties. There is, however, little scientific evidence of the effectiveness or safety of Aloe vera extracts for either cosmetic or medicinal purposes, and what positive evidence is available is frequently contradicted by other studies. Aloe vera has been used as a popular folk medicine. It is a colourless mucilaginous gel obtained from the parenchymatous cells in the fresh leaves of Aloe vera. It has been claimed that Aloe vera gel has the ability to cure gastric ulcers or protect against its formation in both animals and humans. This study evaluates the effect of Aloe vera gel on gastric and duodenal ulcers and determines its interaction with conventionally used antiulcer drugs; pantoprazole. The antiulcer activity of Aloe vera gel at three different doses and its interaction with Pantoprazole was evaluated in, pylorus ligation induced gastric ulcer, stress induced gastric ulcer and  indomethacin induced gastric ulcer  models. In all these models, the common parameter determined was ulcer index. All the three doses of Aloe vera gel produced marginal ulcer healing effect and augmented the ulcer healing effect of pantoprazole in stress and Indomethacin induced gastric ulcers, while in pylorus ligated rats, Aloe vera gel demonstrated gastric anti-secretory and antiulcer effect. Aloe vera gel possesses dose dependent antiulcer effect and augments the antiulcer action pantoprazole in rats.

Keywords: Aloevera gel, gastric cytoprotection, gastric ulcer, pantoprazole.


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