Thu, 23 Nov 2017

Formulation and Evaluation of Matrix Tablet of Cefpodoxime proxetil by Sintering Technique

Dhiraj G. Savant1*, Amit S. Patil1, Roshan P. Vaishnav1, S. H. Majumdar1

1.SVKM’s, School of Pharmacy and Technology Management, NMIMS, Shirpur, Dist. Dhulia, Maharashtra, India


ABSTRACT

The idea of formulation of controlled release drug delivery has become beneficial in the treatment of diseases. At this time, the increased understanding in the community and the significance of safe use of drugs encouraged to develop novel drug delivery system. In the present study, an attempt was made to expand the release of Cefpodoxime proxetil from matrix tablets by sintering technique. This has been an evolving one in the study of effect of heating on mechanical properties of pharmaceutical powders that is used in the formulation of sustained release matrix tablet. The tablets were formulated by direct compression method. The punched tablets were subjected to sintering process and exposed to three different durations of sintering (1.5, 3.0 and 4.5 hours). This type of system provides a important and suitable method for achieving controlled release in oral dosage forms. The release of the drug form un-sintered matrix tablets containing 100 mg polymer was 100% within 90 minutes. For a particular sintering time, the release rate decreased with increasing polymer concentration. For 1.5, 3.0, and 4.5 hours sintering durations the least retardation is offered by least polymer concentration. The highest retardation was offered by matrices with highest polymer concentration.

Keywords: Cefpodoxime proxetil, Sintering technique, Matrix tablets, Direct compression


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