Thu, 23 Nov 2017

Simultaneous Estimation of Cefixime and Linezolid in bulk and tablet dosage form

Jaiprakash N. Sangshetti*1, Baig Salim Rashid1, Sachin Bhojane1, Zahid Zaheer1, Indrajeet Gonjari2

1 Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad-431001

2.Government College of Pharmacy, Karad-415110 (M.S.), India.


ABSTRACT

Simple area under curve spectrophotometric method for determination of Cefixime and Linezolid in bulk and tablet formulation was developed and validated as per ICH guidelines. The lmax of Cefixime and Linezolid were found to be 289nm and 257nm respectively. The linearity range was found 2-12μg/ mL for Cefixime and 5-30μg/mL for Linezolid. In the tablets dosage form Cefixime and Linezolid were estimated as 99.92% and 99.94% respectively. The lower limit of detection (LOD) for Cefixime and Linezolid was found to be 0.039μg/ml and 1.11μg/ml respectively.and the limit of quantization (LOQ) was determined as the lowest concentration for Cefixime and Linezolid was found to be 0.118μg/mL and 3.37μg/ml respectively. The validated spectrophotometric method employed proved to be simple, economical, precise and accurate.

Keywords: Cefixime, Linezolid, UV Spectroscopy, AUC Method.

 


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