Tue, 21 Nov 2017

Formulation and Evaluation of Ethosomes for Transdermal Delivery of Etodolac

Bhale Shweta1, Bhandari Govind1, Pal Pradeep 1,Mahajan S.C.1

1.Mahakal Institute of Pharmaceutical studies, Ujjain (M.P)


ABSTRACT

The objective of work was to formulate, evaluate the potential of ethosomes for delivering etodolace, a potent, water insoluble non‐steroidal anti‐inflammatory drug via skin to enhance skin permeation after topical application. The effects of pH and ethanol contents on etodolac solubility were evaluated to find out the suitable dispersion medium for the ethosome preparations. Drug loaded ethosomes had been prepared using phospholipid and ethanol, were optimized and characterized  for entrapment efficiency, zeta potential, particle size and size distribution. The ethosome were prepared by using the thin film hydration method. The optimized formulation composed of 0. 4% w/v Soya lecithin and 0.1 % pluronic F127 as lipid component and 30% v/v ethanol in phosphate buffer pH 7.4 as dispersion medium. The vesicular size and zeta potential of ethosome was found to be 458.7nm,-36.6 mV respectively The entrapment efficiency was found to be 68.4±0.4%. In final phase of formulation optimized ethosome containing drug, was converted  to gel using three different carbopol 930 concentrations(0.5, 0.7 and 1% w/w).The gel of 0.7% carbopol was found to be the optimized gel  which  shown  excellent in­vitro  drug  release 

Keywords: Ethosome; Ethanol; Transdermal; Phospholipid; In vitro skin permeation, drug loading; flux.


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