DOI: 10.21276/ajptr
Fri, 22 Mar 2019

Characterization of Olive Oil based Microemulsion Drug Delivery System for Oral delivery of Antiulcer agent

Sajal Kumar Jha *1, Roopa Karki2, Venkatesh D P2, B Sajeev3, Geethalakshmi A4

1 Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur, India.

2 Department of Pharmaceutics, Acharya & B M Reddy College of Pharmacy, Bangalore, India.

3  Asian Institute of Medicine Science and Technology, Semeling, Bedong, Malaysia.

4 Department of Pharmaceutics, Oxford College of Pharmacy, Bangalore, India.


The objective of the present research was to develop and characterize an olive oil based oral microemulsion systems for famotidine, is a BCS class III drugs which are known to have high solubility but low permeability. An olive oil based microemulsion formulation with Tween-80 as surfactant, and PEG-400 as co-surfactant, was developed for oral delivery of famotidine. Pseudoternary phase diagram was constructed to determine the microemulsion existing zone. Optimized microemulsion was evaluated for its transparency, droplet size, polydispersity index, zeta potential, viscosity, conductivity, DSC studies, SANS studies. The results showed that maximum oil was incorporated in microemulsion system that was contained surfactant to co-surfactant ratio (Km) of 2:1. The optimized microemulsion formulation containing olive oil (7.14%), Tween-80 & PEG-400 [Smix=64.29% (2:1 ratio)], and distilled water (28.57%), had a droplet size (10 times diluted) and zeta potential (10 times diluted) of 170.1 nm and -6.58 mV respectively. Particle size characterization of the resulting microemulsion is essential in ensuring stability and efficient dosage. FTIR and DSC studies revealed the compatibility among the famotidine and microemulsion components. The experimental SANS data of optimized formulation fit well by spherical micelles interacting with hard sphere potential. These results demonstrate microemulsion formulation may be used as an effective and alternative drug delivery system for the antiulcer oral therapy with famotidine.

Keywords: Famotidine; BCS class III drugs; Olive oil; Pseudoternary phase diagram; Microemulsion

[PDF]   Viewed: 1950   Downloaded: 214
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter