Sat, 18 Nov 2017

Synthesis and Antihypertensive Screening of Novel Substituted 1,2- Pyrazoline Sulfonamide Derivatives

Avinash M. Bhagwat*1, Anilchandra R. Bhat2, Mahesh S. Palled3, Anand P. Khadke1, Anuradha M. Patil4

1.YSPM’s Yashoda Technical Campus, Satara, Maharashtra, India.

2.St James College of Pharmaceutical Sciences, Thrissur, Kerala, India

3.KLEU’s College of Pharmacy, Belgaum, Karnataka, India.

4.JSPM’s Jayawantrao Sawant Institute of Pharmacy, Pune, Maharashtra, India


ABSTRACT

The novel compounds containing two phenyl rings at 3, 5 position of 1, 2-pyrazoline sulphonamide derivatives synthesized. N-((3-(4-aminophenyl)-5-(3,4-disubstitutedphenyl)-4,5-dihydropyrazol-1-yl)methyl)benzenamine screened  for Angiotensin II receptor antagonistic activity  in  1K-1C goldblatt hypertensive rats using tail cuff method. N-((3-(4-aminophenyl)-5-(3,4-dichlorophenyl)-4,5-dihydropyrazol-1-yl)methyl)benzenamine sulphonamide exhibited potent antihypertensive activity.

Keywords: 1,2-pyrazoline, sulfonamide, angiotensin II, antihypertensive


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