Sat, 18 Nov 2017

Synthesis, Characterization And Biological Evaluation Of N-Glucosylated 1,2,4-Dithiazolidines

Snehal A. Chavan1*, Baliram N. Berad1 and Avinash G. Ulhe1

1 P.G. Department of Chemistry, Mahatma Jyotiba Phule Educational Campus,

Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440 033, Maharashtra (India).


ABSTRACT

An efficient synthesis of N-glucosylated 1, 2, 4-dithiazolidines from 1-arylidene-4-arylthiosemicarbazides and N-tetra-O-acetyl-β-D-glucopyranosylimino chloromethane sulphenyl chloride has been worked out. 1-Arylidene-4-arylthiosemicarbazides were synthesized by reacting different aryl/hetero aryl aldehydes/ketones with 4-arylthiosemicarbazides. The identities of new glucosylated heterocycles have been established on the basis of usual chemical transformation, IR, NMR and mass spectral studies. The final compounds were screened for biological activity against different bacterial strains.

Keywords: N-glucosylated 1,2,4-dithiazolidines, 1-arylidene-4-arylthiosemicarbazides, 4-arylthiosemicarbazides


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