Sat, 18 Nov 2017

Evaluation of Hepatoprotective activity of Methanol extract of Curculigo Orchioides in CCl4-Induced Liver Injury in rats

Somesh Thapliyal 1*, Vijay Juyal 2, Anil Bhandari 3

1 Department of Pharmaceutical Sciences HNB Garhwal University, Srinagar Garhwal Uttarakhnd, India

2 Department of Pharmaceutical Sciences, Kumoun University, Bhimtaal, Uttarakhand, India

3 Department of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajesthan, India


ABSTRACT

The present study investigated the hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides (MECO) in CCl4-induced hepatotoxicity model in rats. The hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides were evaluated against CCl4-induced hepatic damage in rats. The three doses of MECO (100, 200 and 400 mg/kg) were administered orally once daily for seven days. Serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP) and total bilirubin were estimated along with the estimation of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissues. Further histopathological examination of the liver sections was carried out to support the induction of hepatotoxicity and hepatoprotective efficacy. The extract revealed significant activities and substantially elevated serum enzymatic levels of AST, ALT, ALP and total bilirubin were found to be normalized significantly by the MECO in a dose dependent manner with maximum hepatoprotection observed at 400 mg/kg dose level. The histopathological observations also indicated the biochemical evidences of hepatoprotection. Elevated level of superoxide dismutase (SOD) and decreased level of malondialdehyde (MDA) further affirmed the hepatoprotective observations. The results of the present study demonstrated that MECO have potent hepatoprotective activity against CCl4-induced hepatic damage in experimental animals.

Keywords: hepatoprotective, antioxidant, carbon tetrachloride, Curculigo orchioides, Silymarin


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