Sat, 18 Nov 2017

New Spectrophotometric Determination of Oxalamine phosphate in Bulk and Pharmaceutical Dosage forms

D.Murali1*, C.Rambabu1

1.Department of Chemistry, Acharya Nagarjuna University, Guntur, A.P, India.


ABSTRACT

Rapid, accurate, precise and economical UV-Visible spectrophotometric methods were developed for the determination of Oxalamine phosphate (OMP) in bulk and pharmaceutical formulations. These methods (Method-A and Method-B) were based on the formation of colored complexes with Iron (III), o-Phenonthroline (M-A) and Cobalt thiocyanate (M-B). The absorbance concentration of plots were linear over the concentration range 10-60µg/ml (Method-A) and 4-24 µg/ml (Method-B) respectively for both methods with a minimum detection limit (LOD) of 2.059 µg/ml (Method-A) and 0.106 µg/ml (Method-B), limit of quantification (LOQ) of 6.240 µg/ml (Method-A) and 3.240 µg/ml (Method-B) respectively. The absorbance was measured at 482 and 620 nm with use of the cited reagents, respectively. The reactions were extremely rapid at room temperature and absorbance values remain unchanged up to 18hrs. Recoveries were 97.90-102.06%. Interferences of the other ingredients and excipients were not observed. The proposed methods are simple and sensitive and this is the first reported complexometric methods for the determination of Oxalamine phosphate (OMP) in commercial tablets.

Keywords: UV-Visible Spectrophotometry; Oxalamine phosphate; o-Phenonthroline; Cobalt thiocyanate

 


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