Sat, 18 Nov 2017

Effect of Taurine on Cytotoxic Markers In 7, 12- DimethylBenz (A) Anthracene Induced Mammary Carcinoma In Experimental Female Sprague-Dawley Rats

Vanitha Kalappan1, Aruldass Ilakkia1, KuppusamyPeriyasamy1, Kuppusamy Baskaran1, Sundaramoorthy Selvaraj1, Dhanapal Sakthisekaran1

1.Department of Medical Biochemistry, University of Madras, Chennai-600113


ABSTRACT

Breast cancer comprises a diverse collection of diseases rather than a single homogeneous disease. Both preclinical and clinical research now commonly target specific subgroups of breast cancer with the aim of identifying biological markers or genetic phenotypes, and to reveal subgroup-specific therapeutic targets or indicators of prognosis. Since genetics is believed to account for only 10% of the reported cases, the environmental factors including diet are thought to play a significant role in predisposing breast cancer. The present study was aimed to evaluate the chemotherapeutic potential of taurine in 7, 12-dimethyl Benz (a) anthracene (DMBA) induced mammary carcinoma in rats. Oral treatment of taurine (100 mg/kg BW) to breast tumor bearing rats daily for ten to fifteen weeks was found to be effective against DMBA induced mammary gland carcinogenesis in female Sprague Dawley rats. The increased activities of 5′-ND, GGT and LDH in tissue of control and experimental breast cancer rats were significantly (p < 0.05) decreased to near normal levels. Thus, the results of the present study clearly indicate that taurine significantly suppresses DMBA induced breast cancer in rats.

Keywords:  Breast cancer, 5’ND, GGT, LDH, Taurine. 


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