Sat, 18 Nov 2017

The effective study of Aqueous extract of Crocus sativus Linn. in Electrical Induced Convulsants in rats.

Sunanda B,P.V1*, Rammohan.B1, Amitabh kumar2, Kudagi BL2

1. Dept. of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore, Tamil Nadu.

2. Dept. of Pharmacology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh.


ABSTRACT

To evaluate the anti-convulsion activity of Crocus sativus linn. aqueous extract  in electrical induced epilepsy models. To compare the anti convulsant activity of crocus sativus linn. with phenytion .After obtaining Institutional Ethical Committee approval, Wistar albino rats (150-200g) of either sex were randomly divided into 5 groups of 6 animals each. Dried powder of crocus sativus linn. was boiled with distilled water, cooled, filtered, placed on hotplate for complete evaporation, finally weighed and stored. The control group, test group and standard drugs group received saline, crocus sativus linn. extract (200,400 & 800 mg/kg), phenytoin (25 mg/kg) respectively by oral feeding. The anti-convulsent effect was assessed by maximal electrical shock (MES) in rats. In electrical induced epilepsy models It implies that saffron 400mg/kg (groupIV) and 800mg/kg(groupV) significantly (p<0.001) delays the onset and significantly (p<0.001) decreased the duration of tonic hind limb extension of MES induced convulsions compared to that of control. The current study demonstrates statistically significant anti-convulsant activity of crocus sativus linn.

Keywords: Crocus sativus Linn., anti-convulsant, MES.


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